Clerodendrum fragrans (Vent) Willd: Review of Pharmacognosy-Phytochemical and Pharmacology

Clerodendrum fragrans (Vent) Willd: Tinjauan Farmakognosi-Fitokimia dan Farmakologi

Authors

  • Donald Emilio Kalonio Jurusan Farmasi, Politeknik Kesehatan Kementerian Kesehatan Manado, Manado, Sulawesi Utara, Indonesia https://orcid.org/0000-0002-8256-3573
  • Elisabeth Natalia Barung Jurusan Farmasi, Politeknik Kesehatan Kementerian Kesehatan Manado, Manado, Sulawesi Utara, Indonesia https://orcid.org/0000-0002-9045-9629
  • Benedicta Irene Rumagit Jurusan Farmasi, Politeknik Kesehatan Kementerian Kesehatan Manado, Manado, Sulawesi Utara, Indonesia
  • Adeanne Caroline Wullur Jurusan Farmasi, Politeknik Kesehatan Kementerian Kesehatan Manado, Manado, Sulawesi Utara, Indonesia
  • Marco Antonio Timpalan Jurusan Farmasi, Politeknik Kesehatan Kementerian Kesehatan Manado, Manado, Sulawesi Utara, Indonesia

DOI:

https://doi.org/10.53770/amhj.v1i4.96

Keywords:

Clerodendrum fragrans (Vent) Willd., Pharmacognosy-Phytochemistry, Pharmacology

Abstract

Introduction: Clerodendrum fragrans (Vent) Willd. was a plant that belongs to the genus Clerodendrum. Plants in this genus have unique species diversity with has wide therapeutic potential. The major phytochemical constituent of this plant was phenolic, flavonoid, terpenoid and steroid. This study was aimed to provide a systematic analysis review of the pharmacognosy-phytochemical aspects and pharmacological activities of C. fragrans (Vent) Willd. The research method was used a literature study. Scientific data searches were conducted on Google Scholar, PubMed, and ScienceDirect online databases using the keywords “Clerodendrum fragrans”, “Clerodendrum chinense”, and “Clerodendrum philippinum”. Based on the scientific data has obtained, the C. fragrans (Vent) Wild. was shown antidiabetic, antimicrobial, antioxidant, analgesic, antipyretic, anti-inflammatory and larvicidal activities. These results have confirmed the potential of C. fragrans (Vent) Willd. as an alternative treatment or as a drug's material resources through various in-vitro and in-vivo tests.

Pendahuluan: Clerodendrum fragrans (Vent) Willd. adalah tanaman yang termasuk dalam genus Clerodendrum. Tanaman dalam genus ini memiliki keanekaragaman jenis yang unik, serta memiliki potensi pemanfaatan dalam terapi yang luas. Kandungan utama dari tanaman ini adalah fenolik, flavonoid, terpenoid dan steroid. Penelitian ini bertujuan untuk memberikan tinjauan analisis sistematis tentang aspek farmakognosi-fitokimia dan aktivitas farmakologi tanaman C. fragrans (Vent) Willd. Metode penelitian yang digunakan adalah studi literatur. Pencarian data ilmiah dilakukan pada database online Google Scholar, PubMed, dan ScienceDirect dengan menggunakan kata kunci “Clerodendrum fragrans”, “Clerodendrum chinense”, dan “Clerodendrum philippinum”. Berdasarkan data ilmiah yang diperoleh tanaman C. fragrans (Vent) Willd memiliki aktivitas aktivitas antidiabetes, antimikroba, antioksidan, analgesik, antipiretik, antiinflamasi dan larvasida. Hasil ini mengkonfirmasi potensi tanaman C. fragrans (Vent) Willd. sebagai alternatif pengobatan atau sebagai bahan baku obat melalui berbagai pengujian in-vitro dan in-vivo.

References

Abouzid, S. F., Wahba, H. M., Elshamy, A., Cos, P., Maes, L., Apers, S., … Shahat, A. A. (2012). Antimicrobial Activity of Some Clerodendrum species from Egypt. Natural Product Research, 1–5. https://doi.org/10.1080/14786419.2012.686905

Afrianti, R., Yenti, R., & Meustika, D. (2014). Analgesic Activity of Papaya Leaf Extract (Carica papaya L.) on Male Mice Induced by Acetic Acid 1%. Jurnal Sains Farmasi & Klinis, 1(1), 54–60. https://doi.org/http://dx.doi.org/10.29208/jsfk.2014.1.1.12

Arini, D. I. D., & Kinho, J. (2015). Keragaman Tumbuhan Berkhasiat Obat Di Hutan Pantai Cagar Alam Tangkoko. Jurnal WASIAN, 2(1), 1–8. Retrieved from https://oaji.net/pdf.html?n=2017/4944-1496728733.pdf

Dhal, P., Rout, J. R., Dash, P. K., Panda, S., Pati, P., Rath, C. C., … Sahoo, S. L. (2018). Larvicidal and Pupicidal Activity of Clerodendrum philippinum Schauer Leaf Extracts against Anopheles stephensi and Aedes aegypti. Pharmacognosy Journal, 10(6), 1137–1142. https://doi.org/10.5530/pj.2018.6.194

Gao, L., Wei, X., & He, Y. (2003). Studies on Chemical Constituents in Leafs of Clerodendron fragrans. China Journal of Chinese Materia Medica, 28(10), 948–951. Retrieved from https://pubmed.ncbi.nlm.nih.gov/15620185/

Kalonio, D. E., Hendriani, R., & Barung, E. N. (2017). Aktivitas Antikanker Tanaman Genus Clerodendrum (Lamiaceae): Sebuah Kajian. Traditional Medicine Journal, 22(3), 182–189. https://doi.org/https://doi.org/10.22146/mot.31554

Kanchanapoom, T., Chumsri, P., Kasai, R., Otsuka, H., & Yamasaki, K. (2005). A New Iridoid Diglycoside from Clerodendrum chinense. Journal of Asian Natural Products Research, 7(3), 269–272. https://doi.org/10.1080/10286020410001690145

Kar, M. K., Swain, T. R., & Mishra, S. K. (2015). Antidiabetic Activity of Clerodendrum philippinum Schauer Leaves in Streptozotocin Induced Diabetic Rats. International Journal of Pharmacy and Pharmaceutical Sciences, 7(9), 386–389. Retrieved from https://innovareacademics.in/journals/index.php/ijpps/article/view/7428

Kew Royal Botanic Garden. (2022). Clerodendrum chinense (specimen K000783980). Retrieved March 10, 2022, from http://apps.kew.org/herbcat/getImage.do?imageBarcode=K000783980

Leeratiwong, C., Chantaranothai, P., & Paton, A. J. (2011). A Synopsis of the Genus Clerodendrum L. (Lamiaceae) in Thailand. Tropical Natural History, 11(2), 177–211. Retrieved from https://li01.tci-thaijo.org/index.php/tnh/article/view/103002

Pranati, D., Krishna, D. P., Ranjan, R. J., Sweta, S., Chandi, R., & Lata, S. S. (2018). Phytochemical Analysis and Antibacterial Activity of Clerodendrum philippinum Schauer. International Journal of Pharmacognosy and Phytochemical Research, 10(4), 170–175. https://doi.org/10.25258/phyto.10.4.9

Pubchem. (2022). Explore Chemistry. Retrieved March 10, 2022, from https://pubchem.ncbi.nlm.nih.gov/

Shrivastava, N., & Patel, T. (2007a). Clerodendrum and Healthcare : An Overview - Part II Phytochemistry and Biotechnology. Medicinal and Aromatic Plant Science and Biotechnology, 1(2), 209–223. Retrieved from http://www.globalsciencebooks.info/Online/GSBOnline/images/0712/MAPSB_1(2)/MAPSB_1(2)209-223o.pdf

Shrivastava, N., & Patel, T. (2007b). Clerodendrum and Heathcare: An Overview. Medicinal and Aromatic Plant Science and Biotechnology, 1(1), 142–150. Retrieved from http://www.globalsciencebooks.info/Online/GSBOnline/images/0706/MAPSB_1(1)/MAPSB_1(1)142-150o.pdf

Simorangkir, M., Hutabarat, W., Nainggolan, B., & Silaban, S. (2019). Antioxidant and Antibacterial Activities of Non-polar to Polar Solvent Extracts of Sarang Banua (Clerodenrum fragrans Vent Willd) Leaves. Rasayan Journal of Chemistry, 12(2), 959–965. https://doi.org/10.31788/RJC.2019.1225095

Simorangkir, M., Nainggolan, B., & Silaban, S. (2018). Secondary Metabolites Phytochemical Analysis of n-Hexane, Ethyl Acetate and Ethanol Extracts of Sarang Banua (Clerodendrum fragrans Vent Willd) Leaves. Proceedings of The 5th Annual International Seminar on Trends in Science and Science Education, AISTSSE 2018. https://doi.org/10.4108/eai.18-10-2018.2287344

Simorangkir, M., Nainggolan, B., & Silaban, S. (2019a). Antioxidant Activity of Vacuum Column Chromatography Fractions of Ethanol Extract of Sarang Banua (Clerodenrum fragrans Vent Willd) Leaves. Journal of Physics: Conference Series, 1374(1), 1–5. https://doi.org/10.1088/1742-6596/1374/1/012016

Simorangkir, M., Nainggolan, B., & Silaban, S. (2019b). Potensi Antibakteri Ekstrak n-Hexana, Etil Asetat, Etanol Daun Sarang Banua (Clerodendrum fragrans Vent Willd) Terhadap Salmonella enterica. Jurnal Biosains, 5(2), 92–98. Retrieved from https://jurnal.unimed.ac.id/2012/index.php/biosains/article/view/13157

Wahba, H. M., Abouzid, S. F., Sleem, A. A., Apers, S., Pieters, L., & Shahat, A. A. (2011). Chemical and Biological Investigation of Some Clerodendrum species cultivated in Egypt. Pharmaceutical Biology, 49(1), 66–72. https://doi.org/10.3109/13880209.2010.494674

Wearn, J. A., & Mabberley, D. J. (2011). Clerodendrum (Lamiaceae) in Borneo. Systematic Botany, 36(4), 1050–1061. Retrieved from https://www.jstor.org/stable/41416920

WFO. (2022). Clerodendrum chinense (Osbeck) Mabb. Retrieved March 10, 2022, from The World Flora Online website: http://www.worldfloraonline.org/taxon/wfo-0000880458

Downloads

Published

2022-03-31

How to Cite

Kalonio, D. E., Barung, E. N., Rumagit, B. I., Wullur, A. C., & Timpalan, M. A. (2022). Clerodendrum fragrans (Vent) Willd: Review of Pharmacognosy-Phytochemical and Pharmacology: Clerodendrum fragrans (Vent) Willd: Tinjauan Farmakognosi-Fitokimia dan Farmakologi. Ahmar Metastasis Health Journal, 1(4), 160–167. https://doi.org/10.53770/amhj.v1i4.96